Rational design of rigid mRNA folding architecture to enhance intracellular processing and protein production - PubMed
3 hours ago
- #protein production
- #mRNA therapy
- #nanoparticles
- Rational design of rigid mRNA folding architecture enhances protein production.
- Metal-ion-assisted RNA folding (MARF) strategy amplifies protein expression up to 7.3-fold.
- Specific metals promote mRNA folding architectures when delivered with lipid nanoparticles (LNPs).
- Enhanced intracellular processing and prolonged mRNA retention in targeted cells.
- Effective and durable genome editing of Pcsk9 gene with a single intravenous dose.
- MARF technology improves mRNA therapy efficacy by leveraging mechanical cues in nanoparticle design.