Exosome-Based Therapeutics in Dermatology and Beyond: A Narrative Review - PubMed

6 hours ago

Exosomes are small extracellular vesicles that act as active messengers between cells, carrying DNA fragments, RNA, lipids, and proteins.
Exosomes regulate various skin functions including inflammation, angiogenesis, matrix remodeling, pigmentation, and hair cycling.
Preclinical models demonstrate benefits such as faster wound closure, improved scar architecture, and stimulation of hair growth.
Early human studies in wound care, rejuvenation, scars, and alopecia show acceptable safety and potential benefits when used with microneedling or lasers.
Exosomes are being explored as acellular alternatives or adjuncts to treatments like platelet-rich plasma and bone marrow aspirate concentrate.
Key challenges include low yields, product heterogeneity, lack of standardized quality metrics, and uncertain regulatory status.
Future success depends on consistent manufacturing, standardized characterization, robust pharmacokinetic data, and long-term comparative trials.

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