Itaconate Modulates Neutrophil Homeostasis to Ameliorate Airway Inflammation in Diesel Exhaust Particles-exacerbated Asthma via Inhibiting NETs Formation - PubMed
4 days ago
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- #asthma
- #itaconate
- Diesel exhaust particles (DEP) exacerbate neutrophilic airway inflammation in asthma, leading to corticosteroid insensitivity.
- Itaconate (ITA), an anti-inflammatory metabolite, was found to be elevated in neutrophils via the NF-κB signaling pathway in DEP-exacerbated asthma.
- Knockout of aconitate decarboxylase 1 (ACOD1) worsened asthma, while exogenous ITA or 4-octyl itaconate (4-OI) treatment reduced airway inflammation and reversed corticosteroid resistance.
- Neutrophil-derived ITA helps maintain immune homeostasis by reducing neutrophil extracellular traps (NETs) formation, which inhibits Th17 cell differentiation.
- ITA serves as a negative regulator of airway inflammation and corticosteroid resistance, showing therapeutic potential for asthma.