Condensation of an H3K9me3 methyltransferase complex promotes heritable gene silencing and heterochromatin formation - PubMed
3 hours ago
- #H3K9me3 methyltransferase
- #biomolecular condensates
- #heterochromatin
- SECP-1 and SECP-2 are identified as cofactors for genome-wide H3K9me3 deposition in C. elegans.
- A complex involving SECP-1, SECP-2, and the H3K9me3 methyltransferase SET-25 forms in the cytoplasm and enters the nucleus via SET-25.
- The complex is recruited to SET-25 genomic targets, leading to condensate formation at repetitive sequences.
- Condensate accumulation correlates with perinuclear heterochromatin localization and inheritance of small RNA-mediated gene silencing.
- Repetitive sequences drive condensate formation, promoting preferential H3K9me3 deposition and heritable gene silencing.