Molecular mechanisms of NLRP3 inflammasome activation - PubMed
3 hours ago
- #NLRP3 inflammasome
- #inflammation
- #immune response
- The NLRP3 inflammasome is a multiprotein complex that activates pro-IL-1β and pro-IL-18 into their active forms.
- Activation involves two signals: Signal 1 induces NLRP3 and cytokine expression, while Signal 2 promotes inflammasome assembly via ionic fluxes, mitochondrial dysfunction, and lysosomal damage.
- Recent studies highlight the complexity of NLRP3 activation, including post-translational modifications and regulatory networks.
- Understanding NLRP3 inflammasome mechanisms could lead to novel therapeutic strategies for diseases linked to its dysregulation.