Piezo1 inhibits diabetic vascular calcification by blocking OGT-mediated RUNX2 O-GlcNAcylation in vascular smooth muscle cells - PubMed
4 hours ago
- #Vascular Calcification
- #Piezo1
- #Diabetes
- Piezo1 inhibits diabetic vascular calcification by blocking OGT-mediated RUNX2 O-GlcNAcylation in vascular smooth muscle cells.
- Arterial calcification is a key pathological marker of diabetic vascular complications, influenced by hyperglycemia, AGEs, and mechanical stress.
- Piezo1 activation exacerbates calcification and O-GlcNAcylation in human coronary smooth muscle cells (HCASMCs), while its inhibition alleviates these effects.
- Mechanistically, Piezo1 interacts with YAP and OGT via calcium-dependent pathways, enhancing RUNX2 O-GlcNAcylation and promoting osteogenic differentiation.
- Targeted Piezo1 ablation in smooth muscle reduces diabetes-related vascular calcification and improves vascular compliance.
- Inhibiting the Piezo1 signaling pathway presents a novel therapeutic approach for diabetic vascular complications.