Ganoderic Acids Alleviate Neuroinflammation by Targeting Myeloid Differentiation Factor 2 for Ischemic Stroke Therapy - PubMed
a day ago
- #ganoderic acid
- #ischemic stroke
- #neuroinflammation
- Ganoderic acids (GAs) from Ganoderma lucidum show anti-inflammatory properties.
- GAs alleviate cerebral ischemic injury and inhibit microglial overactivation in stroke models.
- GA-K, a monomer in GAs, targets myeloid differentiation protein 2 (MD2), blocking TLR4 interaction.
- MD2 overexpression in ischemia is mitigated by GAs, reducing neuroinflammation via MAPK/NF-κB pathways.
- MD2-deficient mice show reduced microglial activation and neuroprotection, unaffected by GAs.
- GA-K's modulation of microglia through MD2 presents a therapeutic target for stroke.