Context-dependent effect of glucocorticoid receptor activity shapes ovarian cancer cell plasticity and therapy response - PubMed
a day ago
- #ovarian cancer
- #therapy resistance
- #glucocorticoid receptor
- The study explores the context-dependent effect of glucocorticoid receptor (GR) activity on ovarian cancer cell plasticity and therapy response.
- Key areas of focus include 3D ovarian cancer models, cell proliferation, cell-cell interactions, drug resistance, metabolic reprogramming, and GR's role.
- Ethical approval was obtained from the Ethics Committee of Azienda Ospedaliera Policlinico, with informed consent from patients enrolled at the University of Campania.
- The authors declare no competing interests, and contributions include research design, patient enrollment, data collection, bioinformatics analysis, and manuscript writing.
- References highlight advances in ovarian cancer diagnosis, heterogeneity, treatment guidelines, and the role of glucocorticoid receptors in therapy.