Artificially constructed collagen-targeting receptors on mesenchymal stromal cells promote anoikis resistance and tissue repair - PubMed
5 days ago
- #anoikis resistance
- #mesenchymal stem cells
- #tissue repair
- Mesenchymal stem cell (MSC)-based therapy shows promise in regenerative medicine but is limited by poor cell survival and engraftment in injury microenvironments.
- Engineered MSCs with von Willebrand factor A3 domain (vWF A3) exhibit enhanced collagen-binding, improving retention in myocardial infarction (MI) and osteoarthritis (OA) lesions.
- vWF A3-MSCs demonstrate improved reparative capacity and anoikis resistance via ECM-receptor interaction and integrin β3 signaling activation.
- These modifications promote proangiogenic effects through MAPK pathway activation and enhance cell survival via Hippo pathway suppression.
- In vivo studies confirm superior therapeutic efficacy of vWF A3-MSCs in MI and OA models, highlighting their potential in regenerative medicine.