Transcriptome analysis of the prefrontal cortex identifies inflammatory genes associated with cognitive impairment in a model of multiple sclerosis - PubMed
3 hours ago
- #cognitive impairment
- #neuroinflammation
- #transcriptome analysis
- Transcriptomic analysis of the prefrontal cortex (PFC) in the EAE mouse model identified strong upregulation of inflammatory pathways, linking inflammation to cognitive impairment (CI) in multiple sclerosis (MS).
- Two inflammation subgroups (EAE-L and EAE-H) were identified, with EAE-H showing more severe inflammation, astrocyte involvement, and downregulation of neuronal genes, suggesting progressive disease stages.
- High expression of genes related to antigen presentation and complement pathways in pre-symptomatic EAE mice was associated with cognitive impairment.
- Increased C1q complement proteins were found in the cerebrospinal fluid of MS patients with cognitive impairment, highlighting potential early biomarkers for CI.
- The study suggests that inflammatory genes in the PFC may serve as early markers and risk factors for cognitive decline in MS patients, with implications for therapeutic strategies.