Overconsumption of fructose aggravates acute GVHD by inducing gut dysbiosis and promoting macrophage-mediated inflammatory response - PubMed
7 hours ago
- #GVHD
- #fructose
- #macrophage
- Overconsumption of fructose worsens acute GVHD by disrupting gut microbiota and increasing inflammatory responses.
- High-fructose diet (HFR) in mice led to severe aGVHD, gut dysbiosis, and intestinal barrier damage.
- Fecal microbiota from HFR-fed mice caused similar disruptions in aGVHD recipients.
- Fructose overexposure activates macrophages via HIF-1α stabilization, increasing glycolysis and inflammatory cytokines.
- Macrophages from HFR-fed mice promoted T-cell proliferation and Th1/Th17 differentiation.
- Depleting macrophages and gut microbiota reversed GVHD severity even with HFR treatment.
- Study suggests dietary fructose adjustment as a potential therapy for aGVHD.