IL-7/IL-15/IL-21 cytokine-fusion scaffold generates highly functional CAR T cells enriched in long-lived T memory stem cells - PubMed
7 hours ago
- #Cytokine scaffold
- #Immunotherapy
- #CAR T cells
- HCW9206, a cytokine-fusion scaffold combining IL-7, IL-15/IL-15Rα complex, and IL-21, generates highly functional CAR T cells without requiring αCD3/28 activation.
- CAR T cells produced with HCW9206 are enriched in long-lived T memory stem cells (TSCM cells) (>50%) and show potent activity in disease models like HIV-1 and B cell leukemia.
- In a humanized mouse HIV infection model, HCW9206-generated anti-HIV duoCAR T cells suppressed viremia more effectively than αCD3/28-generated CAR T cells.
- In a xenograft leukemia mouse model, HCW9206-generated anti-CD19 CAR T cells demonstrated a recall proliferative response and complete clearance of leukemia rechallenge, unlike αCD3/28-generated CAR T cells.
- HCW9206 represents a first-in-class cytokine scaffold-based platform for producing more potent CAR T cell-based immunotherapies with enhanced persistence and functionality.
- The technology is broadly applicable for improving CAR T cell efficacy in treating infectious diseases and cancer.