Intracranial biomarkers for anterior thalamic deep brain stimulation in epilepsy: a long-term observational study - PubMed
4 hours ago
- #biomarkers
- #epilepsy
- #deep brain stimulation
- ANT-DBS is used for drug-refractory epilepsy but outcomes vary, with delayed effects and lack of biomarkers.
- Study analyzed 4-year intracranial recordings from 22 ANT-DBS patients to find biomarkers predicting response.
- Responders showed increased high-frequency (β₁,γ) and decreased low-frequency (δ,θ) activity in ANT over time.
- Biomarkers like β₁/θ ratio allowed early discrimination between responders and non-responders.
- Circadian and multidien rhythms in ANT were identified, supporting adaptive stimulation for better outcomes.
- ANT spectral dynamics may predict efficacy early and guide biomarker-driven optimization of DBS therapy.