Molecular mechanisms of skeletal muscle fibrosis and potential targeted therapeutic strategies - PubMed
5 days ago
- #anti-fibrotic therapy
- #skeletal muscle fibrosis
- #TGF-β/Smad pathway
- Skeletal muscle fibrosis involves excessive ECM deposition, affecting muscle structure and function.
- Key pathways include TGF-β/Smad, YAP/TAZ, inflammation, oxidative stress, and miRNA regulation.
- Fibro/adipogenic progenitors (FAPs), macrophages, and myofibroblasts play critical roles in fibrosis.
- Therapeutic strategies include pharmacological inhibitors, gene therapies, cell-based treatments, and physical interventions.
- Challenges include disease heterogeneity, treatment timing, drug delivery, and long-term safety.
- Future research should focus on targeted therapies, multi-omics, and personalized combination strategies.