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Plasma Proteins Associated With Psychosocial Factors and Heart Disease: The Jackson Heart Study - PubMed

3 hours ago
  • #Psychosocial Factors
  • #Proteomics
  • #Cardiovascular Disease
  • Identifies plasma proteins linked to psychosocial factors and cardiovascular disease in the Jackson Heart Study.
  • Key proteins like Angiopoietin-2 and Macrophage Inhibitory Cytokine 1 are significantly associated with depressive symptoms.
  • Macrophage Inhibitory Cytokine 1 mediates 23% of the link between depressive symptoms and incident coronary heart disease.
  • Study used meta-analyses across multiple cohorts to validate findings, applying strict statistical corrections.
  • Suggests future research on proteomic mechanisms to target psychosocial impacts on cardiovascular health.