GATA1 Drives Human Erythropoiesis via Liquid-Liquid Phase Separation - PubMed
6 days ago
- #LLPS
- #Erythropoiesis
- #GATA1
- GATA1 forms dynamic nuclear condensates in various cell types, exhibiting properties of liquid-liquid phase separation (LLPS).
- Intrinsically disordered region 2 (IDR2) is identified as the primary driver of GATA1 LLPS.
- Mutations like R307H and S310A in IDR2 disrupt GATA1 LLPS, impairing chromatin occupancy and cofactor assembly.
- Loss of LLPS in GATA1 leads to defective erythroid gene activation and terminal differentiation.
- The study suggests modulation of GATA1's IDR2 and post-translational modifications as potential therapeutic strategies for erythroid disorders.