Synaptotagmin 1 and Synaptotagmin 7 promote MR1-mediated presentation of Mycobacterium tuberculosis antigens - PubMed
4 hours ago
- #MAIT cells
- #Mycobacterium tuberculosis
- #antigen presentation
- Synaptotagmin 1 and 7 promote MR1-mediated antigen presentation for Mycobacterium tuberculosis.
- These proteins facilitate MAIT cell activation by aiding MR1 translocation from Mtb vacuoles.
- Loss of Syt1 and Syt7 leads to enlarged MR1 vesicles near Mtb vacuoles in infected cells.
- The pathway involves endosomal calcium signaling critical for presenting scarce Mtb antigens.