Immunotherapy using allogenic NK cells downregulates mitochondrial-related genes and inhibits the OXPHOS system of malignant meningioma - PubMed
2 hours ago
- #neuro-oncology
- #mitochondrial genes
- #immunotherapy
- Allogeneic GiNKs show dose-dependent inhibition of malignant meningioma cell growth by inducing apoptosis in vitro.
- Intracranial administration of GiNKs prolongs survival in orthotopic xenograft mouse models of malignant meningioma.
- RNA sequencing reveals GiNKs downregulate mitochondrial-related genes (MT-ND1, MT-RNR2) and inhibit the OXPHOS system in tumor cells.
- GiNKs may serve as a therapeutic option, potentially combined with immune checkpoint inhibitors, for treating malignant meningioma.