'Oral isotretinoin plus desloratadine for acne vulgaris: an updated global meta-analysis of efficacy, safety, and patient-centered outcomes' - PubMed
4 hours ago
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- #meta-analysis
- Combination therapy of oral isotretinoin plus desloratadine significantly reduces GAGS scores at 4, 12, 16, and 24 weeks compared to isotretinoin monotherapy.
- Higher clinical efficacy (>90% GAGS reduction) observed with combination therapy (OR: 2.39; p = 0.01).
- Combination therapy reduces flare-ups (OR: 0.38; p = 0.009) and pruritus (OR: 0.13; p < 0.00001).
- Greater patient satisfaction with no significant changes in laboratory safety parameters.
- Isotretinoin with desloratadine offers superior efficacy, tolerability, and patient satisfaction without safety risks.