Discovery of synthetic G-quadruplex DNA as SARS-CoV-2 helicase inhibitor with antiviral, anti-inflammatory and antioxidative properties - PubMed
5 hours ago
- #antiviral
- #G-quadruplex
- #SARS-CoV-2
- SARS-CoV-2 RNA contains guanine-rich sequences forming G-quadruplexes (G4s), essential for viral replication.
- Synthetic G4 DNA (GQ20-PTO) inhibits SARS-CoV-2 replication by binding to NSP13 and blocking its helicase and ATPase activity.
- GQ20-PTO also suppresses IFNβ and IL-6 signaling and reduces reactive oxygen species, mitigating hyperinflammation in severe COVID-19.
- G4 quadruplexes like GQ20-PTO represent a novel DNA-based treatment for COVID-19, targeting both viral replication and inflammation.
- Patent application WO2022269013A1 covers the use of G-quartet-forming ODNs for inhibiting viral replication and inflammation.