Colorectal Cancer and Mortality Risk Among Older Adults With vs Without Adenoma on Prior Colonoscopy - PubMed
4 hours ago
- #surveillance colonoscopy
- #colorectal cancer
- #older adults
- A retrospective cohort study investigated colorectal cancer (CRC) risks among adults aged 75+ with vs without adenoma on prior colonoscopy, using data from the US Department of Veterans Affairs.
- Individuals with adenoma had a higher cumulative incidence of CRC (1.1%) and CRC death (0.5%) at 10 years compared to those without adenoma (0.7% and 0.4%, respectively), but absolute risks remained low.
- Non-CRC death was a much more common outcome, with cumulative incidence ranging from 46.9% to 48.4% at 10 years, far exceeding CRC risks across all frailty levels.
- For those with adenoma, the cumulative incidence of non-CRC death at 10 years ranged from 34.2% in nonfrail individuals to 82.0% in severely frail individuals, highlighting significant competing mortality risks.
- The study suggests older adults with prior adenoma may consider deprioritizing surveillance colonoscopy relative to other health concerns, given the low CRC risk compared to non-CRC mortality.