Selenoprotein P Deficiency Is Associated with Early Signs of Kidney Disease and Hospitalization Risk in Heart Failure - PubMed
3 hours ago
- #selenium
- #kidney-disease
- #heart-failure
- Selenoprotein P (SELENOP) deficiency is linked to early kidney dysfunction (SGHS) and higher hospitalization risk in heart failure (HF) patients.
- Study of 570 acute HF patients found 58% had selenium deficiency, 30% had SGHS, and SELENOP levels inversely correlated with SGHS and kidney disease hospitalization risk.
- Higher SELENOP levels reduced odds of SGHS (OR 0.69) and kidney-related hospitalization (HR 0.60), especially acute kidney injury (AKI) (HR 0.42).
- SELENOP deficiency (<3.23 mg/L) predicted AKI hospitalization (HR 4.02), suggesting selenium status impacts HF and renal outcomes.