Combined single-cell transcriptome and immune repertoire analysis reveals hepatic and renal immune injury by heat stroke - PubMed
4 hours ago
- #Heat Stroke
- #Organ Injury
- #Immune Response
- Heat stroke (HS) is a severe heat-related emergency with unclear pathophysiology, especially exertional HS (EHS).
- Single-cell transcriptomics, T cell receptor sequencing, and flow cytometry were used to study PBMCs from healthy controls, heat exhaustion, and EHS patients.
- Granzyme-positive T cells and CD56dim NK cells with high cytotoxicity were enriched in HS.
- IL-1B+NLRP3+ monocytes with high inflammation and pyroptosis scores were also found in HS.
- CD161+ T cells with innate immune-like features were reduced in HS.
- Elevated granzyme-positive T and NK cells may interact with monocytes to induce pyroptosis in hepatic and renal cells.
- Blocking the NLRP3 inflammasome pathway could alleviate organ injury in HS.
- The study provides insights into HS pathogenesis and potential treatment strategies.