Peritumoural adipose tissue drives immune evasion in colorectal cancer via adipose-mesenchymal transformation - PubMed
3 days ago
- #adipose-mesenchymal transformation
- #immune evasion
- #colorectal cancer
- Peritumoural visceral adipose tissue (tVAT) is highly immune-infiltrated in colorectal cancer.
- tVAT competes with tumours for immune cells via the CXCL12-CXCR4 axis, promoting immune escape.
- Tumour-derived factors induce adipose-mesenchymal transformation, creating cancer-associated fibroblasts that secrete CXCL12.
- Targeting adipose-tumour interaction improves the efficacy of anti-PD-1 therapy.
- tVAT is a potential target for enhancing cancer immunotherapy.