KRAS-extrachromosomal DNA drives intratumoral heterogeneity in gastric cancer - PubMed
4 days ago
- #Gastric Cancer
- #KRAS
- #ecDNA
- Extrachromosomal DNA (ecDNA) is a critical oncogene driver in about 20% of tumors, contributing to tumor heterogeneity.
- Gastric cancer frequently exhibits ecDNA, with KRAS being a key amplified oncogene in this context.
- KRAS-ecDNA in gastric cancer leads to elevated KRAS expression and significant transcriptional heterogeneity.
- ecDNA_High cells show enhanced ribosome biogenesis, upregulated DNA repair, and reduced MHC-II signaling, suggesting immune evasion.
- KRAS-ecDNA_High cells are predicted to be sensitive to MAPK inhibitors but resistant to conventional chemotherapies.
- The study highlights the role of KRAS-ecDNA in gastric cancer and suggests targeted strategies for treatment.