Cerebral Toxoplasmosis in a Renal Transplant Recipient-A Rare Complication - PubMed
8 hours ago
- #cerebral toxoplasmosis
- #opportunistic infection
- #renal transplant
- Cerebral toxoplasmosis is a rare but potentially fatal opportunistic infection in renal transplant recipients on long-term immunosuppressive therapy.
- A 70-year-old female kidney transplant recipient presented with headache, mood changes, and right-sided hemiparesis.
- Brain imaging showed a temporoparietal lesion initially suspected as glioblastoma, but histopathology and PCR confirmed Toxoplasma gondii infection.
- Treatment with pyrimethamine, sulfadiazine, leucovorin, and immunosuppressive adjustment led to neurological and radiological improvement.
- The patient died nine months later from multidrug-resistant urosepsis.
- Diagnosis is challenging as radiological findings are nonspecific and can mimic tumors; PCR and histopathology are essential for confirmation.
- Early recognition and anti-toxoplasma therapy are crucial to improve outcomes in immunosuppressed patients with neurological symptoms.