Methylation of MATCAP by PRMT5 regulates microtubule detyrosination to ensure mitotic fidelity - PubMed
a day ago
- #microtubule
- #methylation
- #mitosis
- PRMT5 methylates MATCAP to regulate microtubule detyrosination, ensuring proper mitotic chromosome segregation.
- MATCAP's methylation by PRMT5 at Arg74, Arg99, and Arg104 reduces its microtubule-binding and detyrosination activities.
- Loss of PRMT5 or non-methylatable MATCAP mutants leads to excessive tubulin detyrosination and disrupted chromosome alignment.
- PRMT5-mediated methylation of MATCAP is crucial for maintaining accurate tyrosination levels and mitotic fidelity.