The cGAS-STING pathway in cancer: friend or foe - PubMed
4 hours ago
- #tumor immunity
- #immunotherapy
- #cGAS-STING pathway
- The cGAS-STING pathway detects aberrant cytoplasmic DNA and activates innate immunity, producing type I interferons to trigger antitumor immune responses.
- Its role in cancer is dual, with both antitumor and pro-tumor effects, making it a complex target for immunotherapy.
- This review explores how cGAS avoids self-DNA recognition, details its mechanisms in cancer progression and suppression, and discusses therapeutic strategies.