TUFM: a central regulator in mitochondrial quality control and beyond - PubMed
7 hours ago
- #TUFM
- #cellular homeostasis
- #mitochondrial quality control
- TUFM is a nuclear-encoded GTPase crucial for mitochondrial protein synthesis.
- TUFM regulates mitochondrial quality control, influencing biogenesis, dynamics, and mitophagy.
- Its functions are modulated by post-translational modifications like phosphorylation and acetylation.
- TUFM plays a role in host-pathogen interactions, often exploited by viruses to evade immune responses.
- Hyperactivation of TUFM can promote oncogenesis, while deficiency is linked to neurodegeneration and metabolic disorders.
- TUFM acts as a cellular fate switch, determining survival or death outcomes in various diseases.