RNA modifications in gene regulation: Functions and pathways - PubMed
3 hours ago
- #gene regulation
- #therapeutic strategies
- #RNA modifications
- RNA undergoes over 170 types of chemical modifications.
- Modifications and effector proteins regulate gene expression by controlling RNA fate or local transcription.
- Dynamic biological contexts like cellular state transitions, immune responses, and stress adaptation highlight their importance.
- Focus on mRNA modifications' functional significance and roles of chromatin-associated regulatory RNAs in transcriptional regulation.
- Mechanistic insights guide future research on RNA modifications in gene expression.
- Fundamental understanding is leading to novel therapeutic strategies.
- C.H. has financial interests in several biotech companies related to RNA modifications.