Patterns of Care and Clinical Outcomes in Systemic Peripheral T-cell Lymphoma: The LEO-MER Prospective Cohort Study - PubMed
4 days ago
- #Clinical outcomes
- #CHOP-based therapy
- #Peripheral T-cell lymphoma
- Study focuses on patterns of care and clinical outcomes in systemic peripheral T-cell lymphoma (PTCL).
- Involved 720 patients from two prospective cohort studies: LEO (2015-2020) and MER (2002-2015).
- Primary endpoints were event-free survival (EFS) and overall survival (OS), analyzed using Kaplan-Meier estimator and Cox regression model.
- Most common induction regimens were CHOP-based (70%), including CHOP (36%), CHOP plus etoposide (23%), and CHOP-like plus novel agents (11.5%).
- Consolidative autologous stem cell transplant was performed in 14% of patients.
- Poorer EFS and OS were associated with higher IPI and PIT scores, and non-ALCL subtypes.
- Adding etoposide to CHOP improved OS in ALK-negative ALCL.
- BV-CHP showed a trend toward OS improvement in ALCL.
- Patients failing EFS6 and EFS24 had poor subsequent 5-year OS (12% and 17%, respectively).
- Highlights unmet needs with CHOP-based induction, suggesting prioritization of clinical trials with targeted therapy.