Cadmium treatment induces oxidative damage and apoptosis in vitro skeletal muscle cells - PubMed
3 hours ago
- #Oxidative Stress
- #Apoptosis
- #Cadmium
- Cadmium exposure is a significant risk factor for sarcopenia.
- Study used mouse C2C12 myoblasts exposed to cadmium chloride (0, 2, 4, 8 μmol/L) for 24 hours.
- Cadmium reduces cell viability and increases lactate dehydrogenase release.
- Oxidative-antioxidant imbalance observed: excessive ROS, elevated malondialdehyde, decreased SOD activity.
- Upregulation of Nrf2, HO-1, NQO1, GCLC; downregulation of SOD1 protein.
- Cadmium induces apoptosis via mitochondrial pathway: increased Bax, caspase-3; decreased Bcl-2.
- Findings provide insights into cadmium-induced muscle damage via oxidative injury and apoptosis.