Impaired PIEZO1 function drives uterine hypercontractility in adenomyosis-associated dysmenorrhea - PubMed
3 hours ago
- #adenomyosis
- #PIEZO1
- #dysmenorrhea
- PIEZO1 downregulation in the myometrium reduces eNOS expression and NO production, leading to increased uterine contractility in adenomyosis-associated dysmenorrhea.
- Adenomyosis patients show reduced PIEZO1 and eNOS staining but elevated PIEZO2 and OTR staining, correlating with dysmenorrhea severity.
- Uterine contractile amplitude and irregularity increase progressively in adenomyosis, linked to myometrial fibrosis and altered PIEZO1/PIEZO2 expression.
- PIEZO1 promoter hypermethylation in adenomyosis myometrium can be reactivated by valproic acid (VPA), suggesting potential therapeutic targets.
- Stiffness-dependent changes in PIEZO1, PIEZO2, and OTR expression highlight mechanotransduction's role in adenomyosis progression.
- The study suggests histone deacetylase inhibitors like VPA could be promising for treating adenomyosis by restoring PIEZO1-eNOS function.