Metabolic-Renal Disease Genetics Architecture Revealed by Genomic Structural Equation Modeling - PubMed
19 hours ago
- #Genomic Structural Equation Modeling
- #Metabolic-Renal Axis
- #Lipid Metabolism
- Used genomic structural equation modeling (GSEM) to create the first genetic linkage map for 'Gout-Urate-Kidney-Metabolism' (GUKM) complex.
- Identified 164 lead SNPs, including rs1260326 and rs73607783, and found enrichment in cholesterol and lipid metabolism pathways.
- Tissue and cell enrichment highlighted liver, renal cortex, pancreas, proximal tubular epithelial cells, and hepatocytes.
- Mendelian randomization indicated GCKR as a potential causal gene, highly expressed in liver and hepatocytes, and a core drug target.
- Emphasized lipid metabolism as a key intermediary pathway connecting metabolic and renal diseases, providing insights for genetic mechanisms and intervention targets.