Oleic Acid Promotes Treg Cell Differentiation via Autophagy Induction and Ameliorates DSS-Induced Colitis - PubMed
7 hours ago
- #colitis
- #Treg differentiation
- #autophagy
- Oleic acid (OA) promotes T regulatory cell (Treg) differentiation in a dose-dependent manner.
- OA inhibits mTORC1 activation and promotes AMPK activity, both essential for autophagy.
- Blockade of autophagy abolishes OA-induced Treg differentiation, showing autophagy's necessity.
- In a DSS-induced colitis model, OA increases colonic Treg populations and reduces disease severity.
- OA or diets rich in OA could be supplementary therapies for ulcerative colitis (UC).