Pathogen characteristics are key determinants of distinct host response phenotypes of sepsis - PubMed
3 hours ago
- #immunology
- #pathogen
- #sepsis
- Pathogen characteristics (identity, burden, virulence, and infection site) strongly influence sepsis phenotypes.
- Gram-negative pathogens, especially Enterobacterales spp., are linked to the hyperinflammatory sepsis phenotype.
- Hyperinflammatory phenotype is associated with higher pathogen burden, virulence, and specific infection sites.
- Controlled animal models confirmed pathogen identity and burden trigger hyperinflammatory biological features.
- Lactate clearance's prognostic value varies significantly between sepsis phenotypes.
- Polymyxin B hemoadsorption showed worse survival in hypoinflammatory sepsis patients.
- Understanding pathogen-host interactions is crucial for developing precision sepsis treatments.