Cycloneolitsol prolongs the lifespan of Caenorhabditis elegans by SEK-1/PMK-1/SKN-1 pathway and exerts anti-inflammatory effects by NF-κB pathway - PubMed
5 hours ago
- #Anti-Aging
- #Cycloneolitsol
- #Anti-inflammation
- Cycloneolitsol (CL) extends lifespan in Caenorhabditis elegans via the SEK-1/PMK-1/SKN-1 pathway.
- CL exhibits anti-inflammatory effects by inhibiting the NF-κB signaling pathway in RAW264.7 macrophages.
- Network pharmacology identified core targets and pathways related to CL's anti-aging effects.
- CL activates autophagy and enhances antioxidant stress response in C. elegans.
- The study suggests CL's potential as a natural product for treating inflammation-related diseases and delaying aging.