Efficacy of Lithium Carbonate Combined with Olanzapine, Risperidone, or Quetiapine in Bipolar Disorder Treatment and Effects on Glycolipid Metabolism - PubMed
3 hours ago
- #Bipolar Disorder
- #Lithium Carbonate
- #Glycolipid Metabolism
- Study evaluates lithium carbonate combined with olanzapine, risperidone, or quetiapine in treating bipolar disorder (BD) and effects on glycolipid metabolism.
- 210 BD patients were divided into LO, LR, and LQ groups based on treatment combinations.
- Primary outcomes: Changes in BRMS scores, clinical outcomes, and glycolipid metabolism indicators (TG, TC, HDL, LDL, FBG).
- Secondary outcomes: BD severity (CGI-BP scale) and quality of life (GQOLI-74).
- LR group showed lowest BRMS and CGI-BP scores, highest clinical efficacy, and GQOLI-74 scores.
- LO group had increased TC, TG, LDL; LR group increased TG; LQ group increased TC and TG.
- No significant difference in adverse reactions among groups.
- LR combination recommended for BD treatment due to efficacy and minimal impact on glycolipid metabolism.