Parkinson's disease: pathogenesis and therapeutic strategies - PubMed
2 days ago
- #Alpha-Synuclein
- #Neurodegenerative Disorder
- #Therapeutic Strategies
- Parkinson's disease (PD) is characterized by motor impairments and involves loss of dopaminergic neurons and α-synuclein aggregation in Lewy bodies.
- PD etiology is multifactorial, with pathogenesis driven by α-synuclein aggregation, oxidative stress, mitochondrial dysfunction, and neuroinflammation.
- Current pharmacotherapy, primarily dopamine replacement, only alleviates symptoms without slowing disease progression.
- The review highlights potential treatments like α-synuclein-targeted immunotherapies, iPSC-based regenerative therapies, and gene therapies.
- Future PD management requires integrated, multi-target, and personalized therapeutic strategies to overcome efficacy barriers.