Zolpidem restores sleep and decreases amyloid in a mouse model - PubMed
a day ago
- #Alzheimer's disease
- #sleep
- #amyloid plaques
- Zolpidem restores NREM sleep and rescues sleep-dependent brain rhythms in young APP/PS1 mice.
- Zolpidem administration reduces cortical amyloid plaque burden and mitigates neuronal calcium overload.
- Zolpidem-treated mice show improved sleep-dependent contextual recall without adverse effects on locomotion.
- The study supports zolpidem's therapeutic promise for early-stage Alzheimer's disease intervention.
- Enhancing GABAergic signaling via zolpidem may slow Alzheimer's progression by improving sleep and reducing amyloid.