Collagen I-DDR1 signaling promotes inflammation development during keloid formation - PubMed
4 hours ago
- #keloid
- #inflammation
- #DDR1
- Keloid is a chronic inflammatory skin disease with abnormal fibroproliferative scars and no effective treatments.
- Collagen I-DDR1 signaling promotes inflammation in keloids by activating NFκB and STAT3 pathways.
- DDR1 and ARF6 are upregulated in keloid tissues and their levels are positively correlated.
- DDR1 inhibitor (7rh) and ARF6 inhibitor (NAV-2729) show therapeutic potential in reducing keloid inflammation and growth.
- The ARF6-DDR1 axis facilitates STAT3 phosphorylation, amplifying collagen I-induced inflammation in keloids.
- Combined inhibition of DDR1 and ARF6 synergistically suppresses keloid inflammation.