PRAMEL12 orchestrates spermiogenesis to ensure male fertility in mice - PubMed
4 hours ago
- #chromatin remodeling
- #male infertility
- #spermiogenesis
- PRAMEL12 is essential for male fertility in mice, with its deletion causing complete infertility.
- Pramel12-null mice show severe spermiogenesis defects, including impaired nuclear condensation and spermiation failure.
- Mutant sperm exhibit reduced counts, impaired motility, and increased morphological abnormalities.
- Single-cell RNA sequencing reveals dysregulation of genes critical for sperm chromatin condensation.
- Proteomic profiling indicates significant alterations in proteins vital for sperm structure and function.
- PRAMEL12 deficiency disrupts the histone-to-protamine transition, leading to abnormal histone modifications.
- The study identifies PRAMEL12 as a novel regulator of spermiogenesis and sperm chromatin remodeling.