GFAP+ FOXF2+ ependymal cells promote blood-brain barrier repair via DLL4-NOTCH signaling after neural injury - PubMed
4 hours ago
- #blood-brain barrier
- #ependymal cells
- #neural repair
- GFAP+ FOXF2+ ependymal cells in the subventricular zone (SVZ) expand after neural injury.
- These cells aid in blood-brain barrier (BBB) repair via DLL4-NOTCH signaling.
- GFAP+ FOXF2+ ependymal cells exhibit characteristic ependymal features but do not proliferate.
- Conditional deletion of Foxf2 in GFAP+ cells impairs BBB integrity, while overexpression enhances vascular repair.
- The cells secrete exosomal DLL4, boosting NOTCH pathway activity and BBB restoration.