KIF11 prevents retinal endothelial ferroptosis in familial exudative vitreoretinopathy by inhibiting phosphorylation-driven PRDX1 phase separation - PubMed
4 hours ago
- #ferroptosis
- #retinal endothelial cells
- #familial exudative vitreoretinopathy
- KIF11 prevents retinal endothelial ferroptosis in familial exudative vitreoretinopathy (FEVR).
- FEVR is a hereditary disorder causing severe vision loss in infants and young children, with 40% of cases linked to Norrin/β-catenin pathway mutations.
- KIF11 is identified as a key downstream effector in retinal endothelial cells via RNA sequencing analyses.
- β-catenin/KIF11 deficiency induces autophagy-accompanied ferroptosis, contributing to FEVR pathogenesis.
- KIF11 binds PRDX1, and its disruption leads to Src-mediated PRDX1 phosphorylation and liquid-liquid phase separation.
- Ferroptosis inhibitor ferrostatin-1 and non-phosphorylatable PRDX1 overexpression partially rescue vascular defects in FEVR-associated mice.
- The study highlights the β-catenin/KIF11/PRDX1 axis and suggests ferroptosis-targeting and antioxidant strategies as potential therapies.