Homeostatic maturation programs drive human cDC2s into a tolerogenic state - PubMed
2 days ago
- #immune tolerance
- #dendritic cells
- #Treg cells
- Dendritic cells (DCs) regulate immune activation and tolerance.
- A homeostatic maturation program in type 2 conventional DCs (cDC2s) was identified.
- Homeostatically matured cDC2s (DC2hm) upregulate tolerance-associated transcripts, Treg-polarization machinery, and TSLP receptor complex.
- IL-7Rα+CCR7+ DC2hm can convert naive CD4+ T cells into FOXP3+ Treg cells.
- TSLP stimulation replicates the DC2hm phenotype, indicating its role in DC-mediated tolerance.
- Findings provide insights into autoimmune disease mechanisms and tolerance-inducing therapies.