CD44/POU2F2/BCL9L axis mediates MIF-driven SPP1+TAM activation in colorectal cancer metastasis - PubMed
4 days ago
- #tumor-associated macrophages
- #metastasis
- #colorectal cancer
- The CD44/POU2F2/BCL9L axis plays a crucial role in MIF-driven activation of SPP1+TAMs in colorectal cancer (CRC) metastasis.
- SPP1+TAMs are associated with poor prognosis in CRC, but the underlying mechanisms and therapeutic targets were unclear.
- Single-cell RNA sequencing (scRNA-seq) revealed MIF as a key signaling molecule in the interaction between SPP1+TAMs and CRC cells.
- CD44, co-expressed with SPP1 on TAMs, is essential for MIF-mediated angiogenesis.
- Blocking MIF signaling inhibits SPP1+TAM activation both in vitro and in vivo.
- Clinical data show elevated MIF expression and SPP1+TAM activation in CRC patients.
- POU2F2 is identified as a critical transcription factor in MIF-driven SPP1+TAM activation, with BCL9L as its downstream target.
- Targeting the MIF/CD44/POU2F2/BCL9L axis could be a promising strategy to manage CRC metastasis.