TGF-β and IL-4 + IL-13 induce neuroplasticity in an in vitro model of hPSC-derived sensory neurons - PubMed
5 hours ago
- #cytokines
- #neuroplasticity
- #sensory-neurons
- Chronic type 2 inflammation drives neuroplasticity in vagal nerves, increasing neuronal density and sensitivity, potentially contributing to conditions like eczema and asthma.
- Researchers differentiated sensory neurons from human pluripotent stem cells (hPSCs), validated by markers (β3-tubulin, PGP9.5, TRPV1, Nav1.8, Piezo1/2) and functional tests (calcium imaging, multi-electrode array).
- Exposure to TGF-β or type 2 cytokines (IL-4 + IL-13) induced neuroplasticity-related changes, such as increased network density and neuronal sensitivity, with TGF-β showing stronger effects.
- The study demonstrates the utility of hPSC-derived sensory neurons as a model for investigating neuroplasticity mechanisms and highlights the role of TGF-β and type 2 cytokines in neuroplasticity development.