GPX3 activates autophagy to protect cochlear spiral ganglion neurons from injury in age-related hearing loss - PubMed
3 hours ago
- #Autophagy
- #Age-related hearing loss
- #Oxidative stress
- GPX3 expression decreases in spiral ganglion neurons (SGNs) with aging, leading to increased oxidative stress and apoptosis.
- Autophagy levels in SGNs decline with age, contributing to age-related hearing loss (ARHL).
- Overexpression of GPX3 in SGNs reduces hearing threshold, improves auditory function, and alleviates oxidative stress and apoptosis.
- GPX3's protective effects are mediated through autophagy activation, as blocking autophagy reverses these benefits.
- The small molecule drug ebselen mimics GPX3's effects, reducing SGN damage and improving hearing by activating autophagy.
- Findings suggest GPX3 and autophagy activation as potential therapeutic targets for ARHL.