Legionella Pneumonia in the Modern Era: Clinical Features and Predictors of Mortality - PubMed
a day ago
- #Legionella pneumonia
- #Critical illness
- #Immunocompromised host
- Legionella pneumonia is a significant cause of severe pneumonia with limited contemporary data on its clinical features and outcomes.
- A retrospective multicenter cohort study of 344 adults with confirmed Legionella pneumonia was conducted from 2019 to 2025.
- The median age of patients was 66.6 years, with 45.1% being immunocompromised.
- Most patients required hospitalization (94.2%), with 36.1% admitted to the ICU, 22.7% needing mechanical ventilation, and 1.5% requiring ECMO.
- 30-day and 90-day mortality rates were 11.9% and 16.6%, respectively.
- Independent predictors of 30-day mortality included cirrhosis, immunocompromised status, age, and lymphopenia at presentation.
- Urinary antigen testing was positive in only 25.6% of PCR or culture-positive patients.
- The study highlights the importance of host vulnerability factors in determining outcomes of Legionella pneumonia.