Single-cell transcriptome analysis reveals DNMT1+ epithelial cells promote lymphatic metastasis via CXCL17-mediated TAM infiltration - PubMed
3 hours ago
- #Bladder cancer
- #Lymphatic metastasis
- #Single cell RNA sequencing
- Single-cell transcriptome analysis identifies DNMT1+ epithelial cells as promoters of lymphatic metastasis.
- The study reveals that CXCL17-mediated TAM (tumor-associated macrophage) infiltration is a key mechanism in this process.
- Research was approved by the Ethics Committees of The First Affiliated Hospital of Chongqing Medical University and the Institutional Animal Care and Use Committee.
- The authors declare no conflict of interest.
- References include studies on bladder cancer diagnostics, treatments, and the role of surgery in metastatic bladder cancer.
- Other referenced studies discuss molecular mechanisms like SUMOylation-driven mRNA circularization and fibroblast roles in lymphatic metastasis.